DeOndra Dixon INCLUDE Project Act of 2025

119 HR 3491 EH: DeOndra Dixon INCLUDE Project Act of 2025 U.S. House of Representatives text/xml EN Pursuant to Title 17 Section 105 of the United States Code, this file is not subject to copyright protection and is in the public domain. IB 119th CONGRESS2d Session H. R. 3491

IN THE HOUSE OF REPRESENTATIVES AN ACT To amend the Public Health Service Act to authorize the Secretary of Health and Human Services to carry out a program of research, training, and investigation related to Down syndrome, and for other purposes.

1.Short titleThis Act may be cited as the DeOndra Dixon INCLUDE Project Act of 2025.

2.DeOndra Dixon INCLUDE ProjectPart B of title IV of the Public Health Service Act (42 U.S.C. 284 et seq.) is amended by adding at the end the following: 409K.Down syndrome research (a)In generalThe Director of NIH shall carry out a program of research, training, and investigation related to Down syndrome to be known as the INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE Project or the INCLUDE Project. (b)Program elementsThe program under subsection (a) shall include— (1)high-risk, high-reward research on the effects of trisomy 21 on human development and health; (2)promoting research for participants with Down syndrome across the lifespan, including cohort studies to facilitate improved understanding of Down syndrome and co-occurring conditions and development of new interventions; (3)expanding the number of clinical trials that are inclusive of, or expressly for, participants with Down syndrome, including novel biomedical and pharmacological interventions and other therapies designed to promote or enhance activities of daily living; (4)research on the biological mechanisms in individuals with Down syndrome pertaining to structural, functional, and behavioral anomalies and dysfunction as well as stunted growth; (5)supporting research to improve diagnosis and treatment of conditions co-occurring with Down syndrome, including the identification of biomarkers related to risk factors, diagnosis, and clinical research and therapeutics; (6)research on the causes of increased prevalence, and concurrent treatment, of co-occurring conditions, such as Alzheimer’s disease and related dementias and autoimmunity, in individuals with Down syndrome; and (7)research, training, and investigation on improving the quality of life of individuals with Down syndrome and their families. (c)Coordination; prioritizing nonduplicative researchThe Director of NIH shall ensure that— (1)the programs and activities of the institutes and centers of the National Institutes of Health relating to Down syndrome and co-occurring conditions are coordinated, including through the Office of the Director of NIH and priority-setting reviews conducted pursuant to section 402(b)(3); and (2)such institutes and centers, prioritize, as appropriate, Down syndrome research that does not duplicate existing research activities of the National Institutes of Health. (d)Consultation with stakeholdersIn carrying out activities under this section, the Director of NIH shall, as appropriate and to the maximum extent feasible, consult with relevant stakeholders, including patient advocates, to ensure that such activities take into consideration the needs of individuals with Down syndrome. (e)Biennial reports to Congress (1)In generalThe Director of NIH shall submit, on a biennial basis, to the Committee on Energy and Commerce and the Subcommittee on Labor, Health and Human Services, Education, and Related Agencies of the Committee on Appropriations of the House of Representatives and the Committee on Health, Education, Labor, and Pensions and the Subcommittee on Labor, Health and Human Services, Education, and Related Agencies of the Committee on Appropriations of the Senate, a report that catalogs the research conducted or supported under this section. (2)ContentsEach report under paragraph (1) shall include— (A)identification of the institute or center involved; (B)a statement of whether the research is or was being carried out directly by such institute or center or by multiple institutes and centers; and (C)identification of any resulting real-world evidence that is or may be used for clinical research and medical care for patients with Down syndrome.. Passed the House of Representatives July 20, 2026.Kevin F. McCumber,Clerk.

119 HR 3491 IH: DeOndra Dixon INCLUDE Project Act of 2025 U.S. House of Representatives 2025-05-19 text/xml EN Pursuant to Title 17 Section 105 of the United States Code, this file is not subject to copyright protection and is in the public domain. I119th CONGRESS1st SessionH. R. 3491IN THE HOUSE OF REPRESENTATIVESMay 19, 2025Ms. DeGette (for herself, Mr. Hudson, Ms. DeLauro, Mr. Cole, Ms. Norton, and Mr. Stauber) introduced the following bill; which was referred to the Committee on Energy and CommerceA BILLTo amend the Public Health Service Act to authorize the Secretary of Health and Human Services to carry out a program of research, training, and investigation related to Down syndrome, and for other purposes.

1.Short titleThis Act may be cited as the DeOndra Dixon INCLUDE Project Act of 2025.

2.DeOndra Dixon INCLUDE ProjectPart B of title IV of the Public Health Service Act (42 U.S.C. 284 et seq.) is amended by adding at the end the following: 409K.Down syndrome research (a)In generalThe Director of NIH shall carry out a program of research, training, and investigation related to Down syndrome to be known as the INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE Project or the INCLUDE Project. (b)Program elementsThe program under subsection (a) shall include— (1)high-risk, high-reward research on the effects of trisomy 21 on human development and health; (2)promoting research for participants with Down syndrome across the lifespan, including cohort studies to facilitate improved understanding of Down syndrome and co-occurring conditions and development of new interventions; (3)expanding the number of clinical trials that are inclusive of, or expressly for, participants with Down syndrome, including novel biomedical and pharmacological interventions and other therapies designed to promote or enhance activities of daily living; (4)research on the biological mechanisms in individuals with Down syndrome pertaining to structural, functional, and behavioral anomalies and dysfunction as well as stunted growth; (5)supporting research to improve diagnosis and treatment of conditions co-occurring with Down syndrome, including the identification of biomarkers related to risk factors, diagnosis, and clinical research and therapeutics; (6)research on the causes of increased prevalence, and concurrent treatment, of co-occurring conditions, such as Alzheimer’s disease and related dementias and autoimmunity, in individuals with Down syndrome; and (7)research, training, and investigation on improving the quality of life of individuals with Down syndrome and their families. (c)Coordination; prioritizing nonduplicative researchThe Director of NIH shall ensure that— (1)the programs and activities of the institutes and centers of the National Institutes of Health relating to Down syndrome and co-occurring conditions are coordinated, including through the Office of the Director of NIH and priority-setting reviews conducted pursuant to section 402(b)(3); and (2)such institutes and centers, prioritize, as appropriate, Down syndrome research that does not duplicate existing research activities of the National Institutes of Health. (d)Consultation with stakeholdersIn carrying out activities under this section, the Director of NIH shall, as appropriate and to the maximum extent feasible, consult with relevant stakeholders, including patient advocates, to ensure that such activities take into consideration the needs of individuals with Down syndrome. (e)Biennial reports to Congress (1)In generalThe Director of NIH shall submit, on a biennial basis, to the Committee on Energy and Commerce and the Subcommittee on Labor, Health and Human Services, Education, and Related Agencies of the Committee on Appropriations of the House of Representatives and the Committee on Health, Education, Labor, and Pensions and the Subcommittee on Labor, Health and Human Services, Education, and Related Agencies of the Committee on Appropriations of the Senate, a report that catalogs the research conducted or supported under this section. (2)ContentsEach report under paragraph (1) shall include— (A)identification of the institute or center involved; (B)a statement of whether the research is or was being carried out directly by such institute or center or by multiple institutes and centers; and (C)identification of any resulting real-world evidence that is or may be used for clinical research and medical care for patients with Down syndrome..

119 HR 3491 : DeOndra Dixon INCLUDE Project Act of 2025 U.S. House of Representatives 2026-07-21 text/xml EN Pursuant to Title 17 Section 105 of the United States Code, this file is not subject to copyright protection and is in the public domain. IIB119th CONGRESS2d SessionH. R. 3491IN THE SENATE OF THE UNITED STATESJuly 21, 2026Received; read twice and referred to the Committee on Health, Education, Labor, and PensionsAN ACTTo amend the Public Health Service Act to authorize the Secretary of Health and Human Services to carry out a program of research, training, and investigation related to Down syndrome, and for other purposes.1.Short titleThis Act may be cited as the DeOndra Dixon INCLUDE Project Act of 2025.2.DeOndra Dixon INCLUDE ProjectPart B of title IV of the Public Health Service Act (42 U.S.C. 284 et seq.) is amended by adding at the end the following:409K.Down syndrome research(a)In generalThe Director of NIH shall carry out a program of research, training, and investigation related to Down syndrome to be known as the INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE Project or the INCLUDE Project.(b)Program elementsThe program under subsection (a) shall include—(1)high-risk, high-reward research on the effects of trisomy 21 on human development and health;(2)promoting research for participants with Down syndrome across the lifespan, including cohort studies to facilitate improved understanding of Down syndrome and co-occurring conditions and development of new interventions;(3)expanding the number of clinical trials that are inclusive of, or expressly for, participants with Down syndrome, including novel biomedical and pharmacological interventions and other therapies designed to promote or enhance activities of daily living;(4)research on the biological mechanisms in individuals with Down syndrome pertaining to structural, functional, and behavioral anomalies and dysfunction as well as stunted growth;(5)supporting research to improve diagnosis and treatment of conditions co-occurring with Down syndrome, including the identification of biomarkers related to risk factors, diagnosis, and clinical research and therapeutics;(6)research on the causes of increased prevalence, and concurrent treatment, of co-occurring conditions, such as Alzheimer’s disease and related dementias and autoimmunity, in individuals with Down syndrome; and(7)research, training, and investigation on improving the quality of life of individuals with Down syndrome and their families.(c)Coordination; prioritizing nonduplicative researchThe Director of NIH shall ensure that—(1)the programs and activities of the institutes and centers of the National Institutes of Health relating to Down syndrome and co-occurring conditions are coordinated, including through the Office of the Director of NIH and priority-setting reviews conducted pursuant to section 402(b)(3); and(2)such institutes and centers, prioritize, as appropriate, Down syndrome research that does not duplicate existing research activities of the National Institutes of Health.(d)Consultation with stakeholdersIn carrying out activities under this section, the Director of NIH shall, as appropriate and to the maximum extent feasible, consult with relevant stakeholders, including patient advocates, to ensure that such activities take into consideration the needs of individuals with Down syndrome.(e)Biennial reports to Congress(1)In generalThe Director of NIH shall submit, on a biennial basis, to the Committee on Energy and Commerce and the Subcommittee on Labor, Health and Human Services, Education, and Related Agencies of the Committee on Appropriations of the House of Representatives and the Committee on Health, Education, Labor, and Pensions and the Subcommittee on Labor, Health and Human Services, Education, and Related Agencies of the Committee on Appropriations of the Senate, a report that catalogs the research conducted or supported under this section.(2)ContentsEach report under paragraph (1) shall include—(A)identification of the institute or center involved;(B)a statement of whether the research is or was being carried out directly by such institute or center or by multiple institutes and centers; and(C)identification of any resulting real-world evidence that is or may be used for clinical research and medical care for patients with Down syndrome..Passed the House of Representatives July 20, 2026.Kevin F. McCumber,Clerk.

119 HR 3491 RH: DeOndra Dixon INCLUDE Project Act of 2025 U.S. House of Representatives 2026-07-02 text/xml EN Pursuant to Title 17 Section 105 of the United States Code, this file is not subject to copyright protection and is in the public domain. IBUnion Calendar No. 627119th CONGRESS2d SessionH. R. 3491[Report No. 119–722]IN THE HOUSE OF REPRESENTATIVESMay 19, 2025Ms. DeGette (for herself, Mr. Hudson, Ms. DeLauro, Mr. Cole, Ms. Norton, and Mr. Stauber) introduced the following bill; which was referred to the Committee on Energy and CommerceJuly 2, 2026Additional sponsors: Mr. Tonko, Ms. Pettersen, Ms. Craig, Mr. Crow, Mr. Neguse, Mr. Pocan, Mrs. Wagner, Ms. Ross, Mr. Kustoff, Mr. Subramanyam, Mr. Nadler, Mr. Walkinshaw, and Mr. WittmanJuly 2, 2026Committed to the Committee of the Whole House on the State of the Union and ordered to be printedA BILLTo amend the Public Health Service Act to authorize the Secretary of Health and Human Services to carry out a program of research, training, and investigation related to Down syndrome, and for other purposes.1.Short titleThis Act may be cited as the DeOndra Dixon INCLUDE Project Act of 2025.2.DeOndra Dixon INCLUDE ProjectPart B of title IV of the Public Health Service Act (42 U.S.C. 284 et seq.) is amended by adding at the end the following:409K.Down syndrome research(a)In generalThe Director of NIH shall carry out a program of research, training, and investigation related to Down syndrome to be known as the INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE Project or the INCLUDE Project.(b)Program elementsThe program under subsection (a) shall include—(1)high-risk, high-reward research on the effects of trisomy 21 on human development and health;(2)promoting research for participants with Down syndrome across the lifespan, including cohort studies to facilitate improved understanding of Down syndrome and co-occurring conditions and development of new interventions;(3)expanding the number of clinical trials that are inclusive of, or expressly for, participants with Down syndrome, including novel biomedical and pharmacological interventions and other therapies designed to promote or enhance activities of daily living;(4)research on the biological mechanisms in individuals with Down syndrome pertaining to structural, functional, and behavioral anomalies and dysfunction as well as stunted growth;(5)supporting research to improve diagnosis and treatment of conditions co-occurring with Down syndrome, including the identification of biomarkers related to risk factors, diagnosis, and clinical research and therapeutics;(6)research on the causes of increased prevalence, and concurrent treatment, of co-occurring conditions, such as Alzheimer’s disease and related dementias and autoimmunity, in individuals with Down syndrome; and(7)research, training, and investigation on improving the quality of life of individuals with Down syndrome and their families.(c)Coordination; prioritizing nonduplicative researchThe Director of NIH shall ensure that—(1)the programs and activities of the institutes and centers of the National Institutes of Health relating to Down syndrome and co-occurring conditions are coordinated, including through the Office of the Director of NIH and priority-setting reviews conducted pursuant to section 402(b)(3); and(2)such institutes and centers, prioritize, as appropriate, Down syndrome research that does not duplicate existing research activities of the National Institutes of Health.(d)Consultation with stakeholdersIn carrying out activities under this section, the Director of NIH shall, as appropriate and to the maximum extent feasible, consult with relevant stakeholders, including patient advocates, to ensure that such activities take into consideration the needs of individuals with Down syndrome.(e)Biennial reports to Congress(1)In generalThe Director of NIH shall submit, on a biennial basis, to the Committee on Energy and Commerce and the Subcommittee on Labor, Health and Human Services, Education, and Related Agencies of the Committee on Appropriations of the House of Representatives and the Committee on Health, Education, Labor, and Pensions and the Subcommittee on Labor, Health and Human Services, Education, and Related Agencies of the Committee on Appropriations of the Senate, a report that catalogs the research conducted or supported under this section.(2)ContentsEach report under paragraph (1) shall include—(A)identification of the institute or center involved;(B)a statement of whether the research is or was being carried out directly by such institute or center or by multiple institutes and centers; and(C)identification of any resulting real-world evidence that is or may be used for clinical research and medical care for patients with Down syndrome..July 2, 2026Committed to the Committee of the Whole House on the State of the Union and ordered to be printed